Wednesday, March 31, 2010

Sleep Apnea and Resistant Hypertension

The March issue of Renal and Urology News reported on a new study linking reduced sleep duration with resistant hypertension (RH). RH patients are drug-resistant to hypertension medications.

The study was published in the April issue of the American Journal of Hypertension.

The researchers examined overnight PSG results for 151 patients.

Sixty-two patients had RH. Forty-nine patients had controlled hypertension (CH). And forty patients had normal blood pressure (BP).

The patients had equally severe obstructive sleep apnea (OSA). But patients with CH and normal BP had better sleep quality than those with RH.

Even after adjusting for age, gender, body mass index, apnea–hypopnea index, and diabetes, the differences were clear. On average, patients with RH slept 33.8 minutes less than those with CH. They slept 37.2 minutes less than those with normal BP.

Sleep efficiency, or total sleep time as a percent of time spent in bed, was also lower in RH patients. Drug-resistant patients had 7.9 percent and 10.2 percent lower efficiency than CH and normal BP patients, respectively.

The RH group spent 9.7 minutes less time in rapid eye movement (REM) sleep, which is when dreams occur, than the CH group. They spent 11.6 minutes less in REM sleep than the normal BP group.

The researchers noted that past studies have found that sleep deprivation can worsen arterial pressure and hypertension in humans and animals. Together with past studies, these results suggest that reduced sleep time may contribute to RH.

Last November, this blog reported on a study showing that oral appliance therapy can reduce hypertension in OSA patients.

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The Official Blog of the American Academy of Dental Sleep Medicine (AADSM) is intended as an information source only. Content of this blog should not be used for self-diagnosis or treatment, and it is not a substitute for medical care, which should be provided by the appropriate health care professional. If you suspect you have a sleep-related breathing disorder, such as obstructive sleep apnea (OSA), you should consult your personal physician or visit an AASM-accredited sleep disorders center. The AADSM, and the American Academy of Sleep Medicine, as the managing agent of the AADSM, assume no liability for the information contained on the Official Blog of the AADSM or for its use.